Formulation and Evaluation of Diclofenac Sodium as a Topical Preparation

Ahmed Yas, Ali

	Formulation and Evaluation of Diclofenac Sodium as a Topical Preparation
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 2, Issue 2, 2006, Pages 122-131
Author
Ali Ahmed Yas
Abstract
The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of w/o microemulsion (M) and gel (G) bases for diclofenac sodium (DS). The effect of dimethyl sulfoxide (DMSO) as a penetration enhancer was also examined when it was added to the M formulation. To study the in vitro potential of these formulations, permeation studies were performed with Franz diffusion cells using excised dorsal rat skin. To investigate their in vivo perfoniranc e, a car-rageenan - induced rat paw edema model was used. The commercial formulation of DS (C) was used as a reference formulation. The results of the in vitro permeation studies and the paw edema tests were analyzed by repeated - measures analysis of variance. The in vitro permeation studies found that M was superior to G and C and that adding DMSO to M increased permeation rate. The permeability coefficient (Kp) of DS from M and M + DMSO were higher (Kp :4.9 X 10 -3 +3.6 X l0 -4 cm lhand 5.3 X 10 -3 + l.2X 10 -3 cm / h, respectively) than the ($p) of nS from C (Kp: 2.7 xl0-3 +7.3 X 10 -4 cm /h) and G (Kp:4.5 X i0 -3 x+.s X 10 -s cm / h). In the paw edema test, M showed the best permeation and effectiveness, and M + DMSO had nearly the same effect as M. The in vitro and in vivo studies showed that M could be a new, altemative dosage form for effective therapy.

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