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New and Developed Method to Prepare 1,1-Bis (4-chlorophenyl) ethanol and 1,1-Bis (4-chlorophenyl)-2,2,2-trichloroethanol | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 14, Issue 2, 2009, Pages 75-79 | ||
| Author | ||
| Sami A. Ali | ||
| Abstract | ||
| 1,1-Bis (4-chlorophenyl) ethanol and 1,1-Bis (4-chlorophenyl)-2,2,2-trichloroethanol (which are the active ingredient of Qikron and Dicofol pesticides) were synthesized via developed and derived procedure. Treatment of phenyl magnesium bromide (Gringard reagent) with acetophenone gave the 1,1-diphenyl ethanol, chlorination of the obtained product in glacial acetic acid gave 1,1-Bis (4-chlorophenyl) ethanol in good yield. Chlorination of the methyl group in the obtained product in presence of ultraviolet light (UV) and heat gave the 1,1-Bis (4-chlorophenyl)-2,2,2-trichloroethanol in good yield. The products were identified by physical, chemical, spectroscopic and element analysis. The bioassay was also measured for the obtained compounds. | ||
| Keywords | ||
| Qikron; Dicofol | ||
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