Formation - Extraction of Ion-Pair for Isoniazid and Chloroquine Sulphate Drugs with [PdI4]-2 and Determination by Molecular Absorption

T. Amine, Suham

	Formation - Extraction of Ion-Pair for Isoniazid and Chloroquine Sulphate Drugs with [PdI4]-2 and Determination by Molecular Absorption
Tikrit Journal of Pure Science
Article 1, Volume 14, Issue 2, 2009, Pages 245-252
Author
Suham T. Amine
Abstract
This research includes the determination of Isoniazid(INH) and Chloroquine Sulphate (CqS) drugs by the formation of ion association pairs with [PdI4]-2 complex . Red–brown color solution is formed which give maxmum absorption at λ= 284 and 362 nm for Isoniazid and at 294 and 360 nm for CqS . The analytical results are as follow : 1- The optimum conditions for the determination of Isoniazid by forming the ion association pair with [PdI4]-2 were : pH= 1.5, reaction time of 15 minutes, with ratio of (4 ml of organic phase/ 5 ml of aqueous phase) and mixing time is not exceeding 4 minutes and the best organic solvent was found to be 1,2- dichloroethane The statistical and other analytical results for the concentration range (1.0–17.5) ppm were as follow: Correlation coefficient r = 0.9990 and r = 0.9995, detection limit is 0.0151 and 0.0227 ppm, Molar absorption coefficient is 9226.83 and 10104.27 L/mol.cm, Sandel,s sensitivity is 0.0149 and 0.0136 µg/cm2 and RSD 0.0761% and 0.1692 at λ= 284 and 362 nm respectively, the ion pair showed good stability with the time . This method was applied for the determination of Isoniazid in tablets with recovery of 100.45 % for direct method and was 96.67 % for standard addition method . 2- Similarly, CqS was determined with optimum conditions of pH = 3 , the ratio was ( 4 ml of organic phase / 5 ml of aqueous phase ) and the mixing time does not exceed 1 minute . the best organic solvent was 1,2- dichloroethane . The statistical and other analytical results for the concentration range (12.5 – 0.5) ppm were as follow : Correlation coefficient r = 0.9995 and r = 0.9994, detection limit is 0.0173 and 0.0131 ppm, molar absorption coefficient is 51709.6 and 26508.8 L/mol.cm, Sandel,s sensitivity is 0.0084 and 0.0164 µg/cm2 and RSD 0.0847% and 0.8837% at 294 and 360 nm respectively, the ion pair showed good stability with time.
Keywords
PdI

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