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Congenital Immunity Modulation in Toxoplasmosis using Lipopolysaccharide of Escherichia coli | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 14, Issue 2, 2009, Pages 238-244 | ||
| Author | ||
| Ibtisam M. Yaseen | ||
| Abstract | ||
| The effect of lipopolysaccharide (LpS) extracted from Escherichia coli was investigated on non-specific cellular immunity represented by phagocytosis and on total and differential count of leucocytes in BALB/C mice infected with toxoplasmosis. By measurement of phagocytic index in activated mice with LpS in comparison with the control. The results revealed that phagocytosis was significantly higher in mice activated with LpS represented by an increase in the phagocytic index (94.11%) at 2000 g /20gm body weight . The results showed that LpS activates macrophage and stimulates proliferation of lymphocytes and infiltration and migration of neutrophils and monocytes to the sites of infection. It appeared that the LpS extract was a non- specific immune modulator to macrophages and had the ability to enhance the immune system of mice against this infection. | ||
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