MANNICH BASE DERIVED FROM 1,3,4-THIADIAZOLE AS CHELATING LIGAND FOR SOME TRANSITION METAL COMPLEXES

A.M.Al-Hasani, Rehab

	MANNICH BASE DERIVED FROM 1,3,4-THIADIAZOLE AS CHELATING LIGAND FOR SOME TRANSITION METAL COMPLEXES
Journal of Al-Nahrain University - Science
Article 1, Volume 11, Issue 2, 2008, Pages 42-56
Author
Rehab A.M.Al-Hasani
Abstract
The compound(5-phenyl-1,3,4- thiadiazole-3-one) react with dibenzylamine and formaline to form new mannich base {N(2-(5-phenyl-1,3,4-thiadiazole-3-one)methyl) dibenzylamine} (DB).The product was characterized by (FT-IR) Spectroscopy and thermal analysis(TG-DTG). (DB) act as a ligand coordinating with some transiton metal ions{Co(II), Ni(II), Cu(II), Pd(II), Cr(III), Fe(III), Ru(III), Rh(III), Au(III), and Pt(IV)} through the oxygen of carbonyle group and the nitrogen of the amino methyl group.The steroochemistry around the metal ion has been suggested using flame atomic absorption, (FT-IR) and (UV-Vis) Spectroscopy, in addition to magnetic susceptibility , conductivity measurement and thermal analysis(TG-DTG). The study of the nature of the complexes formed in (ethanolic solution) following the mole ratio method, gave results which were compared successfully with those obtained from solid state studies. The apparent stability constant of the complexes have been studied with the time and their color were stable for more than (6) hours, as well as the molar absorptivities have been calculated.The antibacterial activity for the ligand and their metal complexes were studied against four selected microorganisms [(Pseudo monase aeruginos) and (Klesbiella pneumonia) as gram negative] and [(Streptococcus faecalis) and( Bacillus subtlus) as gram positive]. The minimal inhibitory concentration (MIC) have been also studied to determined the low concentration for inhibition. Further more the antifungl activity against two micro-organism (Candida albicans and Aspergillus flavus) were studied for the ligand and their metal complexes.

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