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The Histological and Biochemical Changes Resulted From Feeding of White New Zealand Rabbits on Cholesterol and Vitamin E | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 4, Issue 0, 2011, Pages 1-18 PDF (439.94 K) | ||
| Authors | ||
| H. Sh. Abid; M. S. Shallal; L. H. Ali | ||
| Abstract | ||
| This study was conducted to reveal the effects of vitamin E and cholesterol on white New Zealand rabbits. Cholesterol and vitamin E were added in their diets with a certain percent to each group. Other animals were divided into four groups in order to study the resulted histological and biochemical changes. The first group was given a normal diet (no addition of cholesterol or vitamin E), the second and the third groups were given 2% cholesterol and 2% cholesterol with 1% vitamin E, respectively. The fourth group was given 2% cholesterol for eight weeks till they had diagnosed to have atherosclerosis and then given 1% vitamin E for four weeks after infection ANOVA table was used to compare the mathematical means through the least significant values test, (L.S.D) among treatments that were replicated three times, at α levels 0.01 and 0.05. Results showed the followings: - The addition of 1% vitamin E with 2% of Cholesterol to the diet decreased the average of the total cholesterol (TC), low dense lipoproteins (LDL) and triglycerides (TG). TC values in the first group were 149.8±1.923, 153.4±1.673, 154.8±1.923 and 158.6±2.701 mg/dl for the first day of the first week, and the 4th, 8th, and 12th weeks, respectively. TC averages in the second group were 149.4±2.408, 353.2±3.492, 392.0±43.663 and 521.0±4.582 mg/dl., in the third group were 146.0±3.608, 215.0±2.449, 189.6±2.408 and 176.2±3.701 mg/dl.,and in the fourth group were 150.6±2.509, 218.0±2.449, 402.6±3.847 and 221.4±4.159 mg/dl., for the first day of the first week, and the 4th, 8th and 12th weeks, respectively. - Low dense (LDL) and the very low dense lipoproteins (VLDL) gave similar reactions to the total cholesterol percentages as to their increase in the second group and gave a gradual decrease in the third and fourth groups. High dense lipoproteins (HDL) gave similar averages as to control at the same various specified times of the experiment. - The number of foam cells had increased gradually from the fourth week and also, the collagen and elastic fibers in addition to smooth muscles of the endothelium, the reason to which its thickness had increased. The medium tunica had a number of foam cells and other gradual difference in its compact components especially the elastic and other muscular fibers the reasons to which its thickness had decreased. - The cure by the addition of 1% vitamin E to the diet decreased the mentioned changes especially in the first eight weeks and also decreased the height of the endothelium thickness with a decrease of foam cells in the third group and other changes in the fourth group. - There was a clear increase in the endothelium thickness, but the thickness in the medium tunica had decreased as compared to control and to the group affected with hypercholesterolemia. - Vitamin E can keep and fix most of the changes resulted from high cholesterol in the third and fourth groups. | ||
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