Effect of fish oil and unsaturated fatty acidOmega-3 on fertility of  female's albino rats Rattus rattus

	Effect of fish oil and unsaturated fatty acidOmega-3 on fertility of female's albino rats Rattus rattus
Magazine of Al-Kufa University for Biology
Article 1, Volume 3, Issue 2, 2011, Pages 278-290
Abstract
The objective of this study was to evaluate the effects of orally supplementing fish oil and omega-3 fatty acids during the proestrous on fertility of female's rats.) White female rats Rattus rattus were used in the study, each rat Weighed about (200-250) gr., and aged about (12-14) week. Results indicates that LD50 of fish oil and omega- 3 after orally administered of females rats by different concentrations (100,200,.400,600,800,1000 and 1200) mg/rats are (750)mg/rats and (950)mg/rats, respectively. Results shows a significant increase (p< 0.05) in the weight of the ovary for both concentrations (200,400) mg/ rats for rats treated by fish oil and omega- 3 Respectively, comparing with control group , the results shown a significant increase ( p< 0.05 ) in the weight of uterus for both concentrations (200,400) mg/rats for fish oil and omega-3 treated rats respectively comparing with control group, the concentrations (400) mg/kg was higher effective than (100, 200) mg / kg respectively on the of ovarian and uterus weight. Results are indicates that a significant increase(p<0.05) in the level of follicle stimulating hormone (FSH) for all concentration (100 .200 .400 )mg/kg , whereas they are no significant differences in the level of luteinizing hormone (LH) for all concentrations as comparing with control group. Results appear a significant increase (p<0.05) in the level of estrogen hormone for both concentrations (200.400) mg/kg as comparing with control group. The statistical analysis are shown a significant increase (p<0.05) of the level of (FSH) and estrogen hormones in omega-3 group as comparing with fish oil group. The histological study shown a significant increase (p<0.05) in the number of primary and secondary follicles for fish oil and omega-3 at all concentration (100, 200, 400) mg/kg for omega-3 respectively as comparing with control groups They are shown no significant differences (p<0.05) at all concentrations of fish oil and omega-3 in Graffian follicles numbers. A result shows a significant increase of in the thickness of endometrium (p< 0.05) at all concentrations for fish oil and omega-3 respectively as comparing with control groups. Fertility test show a significant increase (p< 0.05) in the numbers of embryos at concentrations (200,400) mg/kg for omega-3 and fish oil respectively as comparing with control group .There are no significant differences in the percentage of pregnancy and normal embryos between fish oil and omega-3 as comparing with control groups.

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