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Synthesis and biological studies of mono, Bis 1,3,4- thiadiazole-2-amino derivatives | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 11, Issue 2, 2006, Pages 171-177 | ||
| Author | ||
| Ahmed SH. Hamed | ||
| Abstract | ||
| In the present study, two methods (ordinary and acid chloride methods) were used to prepare new hydrazides and thiosemicarbazides derivatives from the mono and dicarboxylic acid: 1- Oxalic acid, 2-Malonic acid, 3-Succinic acid, 4-Adipic acid, 5-Pimelic acid, 6-Sebacic acid, 7-Palmitic acid, 8-Cinnamic acid, 9- 2,5-dihydroxy Benzoic acid and 10-Quinaldic acid. These thiosemicarbazide derivatives were converted to 2-Amino- 1,3,4-thiadiazole by ring closer. The direct reaction of carboxylic acid and thiosemicarbazide in concentrated H2SO4 was used for the first time in this conversion as well. The prepared derivatives were identified by using melting point and infrared spectra studies. The antibacteria strains has been investigated; an activity has been shown against Gram(+ve) bacteria (Staphylococcus aureus) and Gram (-ve) bacteria (Escherichia coli). | ||
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