Morphological malformatios and histological defects of some central nervous system divisions during embryogenesis of albino mice Mus musculus induced by ethyl alcohol

Ashgar Abd, Ali

	Morphological malformatios and histological defects of some central nervous system divisions during embryogenesis of albino mice Mus musculus induced by ethyl alcohol
Tikrit Journal of Pure Science
Article 1, Volume 11, Issue 2, 2006, Pages 137-144
Author
Ali Ashgar Abd
Abstract
The present study carried out to investigate the mophological malformations as well as histopathological lesions in some divisions of central nervous system created by ethyl alcohol during embryogenesis of albino mice Mus musculus at the level of light microscope. The pregnant female ingested alcoholic solution orally as ascending concentrations (15%,20%,25%,30%). The results revealed no pregnant period prolongation in contrast to control group i.e 18 days. At 15% concent. no morphological or histological lesions were observed. While at 20% concent. there were 22% injured embryos. The morphological malformations represented as skull depression and micromelia, while the histological lesions were rarefaction, Hyperplasia, bleeding in the two lobel of telencephalon. The ratio of defect embryos at 25% concent. was 24%. The mophological defects were dermalaxia, crispation, exophthalmia.Histopathologicaly the injuries were vaculation, necrosis, oedema of neuroepithelium of telencephalon, crenation and shrinkage of eye lens as well as spinal cord injuries also noticed 31% malformed embryos were observed at 30% alcoholic concent, morphologicaly the lesions were abdominal dermalaxia and constriction, limbs defects. The histopathological injuries appeared as neuroepithelial destruction of prosencephalon, wide defects in spinal cord as well as spinal control structure.

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