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The effect of Water and alcohol extract of Cymbopogon citratus on blood Glucose level and Some Biochemical parameters in normal and experimental Diabetic Male Rats. | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 11, Issue 2, 2006, Pages 66-72 | ||
| Author | ||
| Saleh M. Rahim Al- Obaidy | ||
| Abstract | ||
| The Study was designed to investigate the effect of water and alchol extract of Cymbopgon citratus on the level of glucose and some biochemical parameters (Cholestrol, Triglycerides, Total protein , Urea and Creatinin) and body weight in normal and Alloxan –induced diabetic male rats. The effect of extracts histotoxicity in some tissues of male rats (Pancrease, Liver, Kidney, Brain and Small intestine) were also studied, and all results were compared with Glibenclamide as control chemical drugs. The results of study revealed that alcohol extract produced significant decrease (P<0.05) in glucose level and all the biochemical parameters studied in diabetic male rats and this effect was similar in normal male rats except at the level of total protein and urea which showed non- significant changes. Water extract caused a significant decrease (P<0.05) in glucose level and all the biochemical parameters except total protein level in diabetic animals , wherease in normal animal this significant decrease didn’t appear only in glucose level , body weight, cholesterol, trglyceride. The result demonstrated that there are significant (P<0.05) difference between the effect of both water and alchol extracts in the levels of glucose, trglyceide, total protein, and creatinine in diabetic rat only. Also the results referred that the effect of water and alcohol extracts is as effective as control chemical drug (Glibenclamide). The histological results showed no tissue changes where clear and recognizable in the normal males rat which are treated or not treated while in the abnormal tested animals the kidney show only simple tissue changes which was caused by the increasing of blood glucose. The untreated abnormal animals provided less tissue changes. The results obtained from this study suggest that these extracts may be used for the treatment of diabetes mellitus particularly the alcohol extracts after be sure that there are no side effects for it. | ||
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