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Spectrophotometric Determination of some Phenothiazines Using N-Chlorosuccinimide | ||
| Rafidain Journal of Science | ||
| Article 4, Volume 20, Issue 8, 2009, Pages 27-37 PDF (0 K) | ||
| DOI: 10.33899/rjs.2009.39917 | ||
| Authors | ||
| Theia N. Al-Sabha1; Saladdin M. Al-Talib* 2 | ||
| 1Department of Chemistry, College of Education , Mosul University | ||
| 2Medical Technical Institute, Mosul | ||
| Abstract | ||
| A simple and sensitive spectrophotometric method has been developed for the determination of some phenothiazine derivatives as pure and in dosage form. The method is based on oxidation of phenothiazines by N-chlorosuccinimide in hydrochloric acid medium to give red coloured species having maximum absorptions in the range 516.5-534.5nm. Beer‘s law is obeyed over the concentration ranges 2-28, 2-32 and 4-40µg.ml-1 with apparent molar absorptivity of 6.16×10³, 5.89×10³ and 5.34×10³ l.mol-1.cm-1 for phenothiazine, promethazine hydrochloride and chlorpromazine hydrochloride respectively. Additives and excipients normally found in dosage forms do not interfere. | ||
| Keywords | ||
| phenothiazines; Determination; chlorosuccinimide; spectrophotometry | ||
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