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Spectrophotometric Determination of Phenylephrine Hydrochloride by Coupling with Diazotized 2- Aminobenzothiazole | ||
| Rafidain Journal of Science | ||
| Article 8, Volume 20, Issue 8, 2009, Pages 69-81 PDF (0 K) | ||
| DOI: 10.33899/rjs.2009.39971 | ||
| Authors | ||
| Noha Th. Abdul Fatah; Nabeel S. Othman | ||
| Abstract | ||
| A spectrophotometric method for determination of microgram amounts of phenylephrine-HCl(PE) has been proposed. The method is based on coupling of phenylephrine-HCl with diazotized 2-aminobenzothiazole in alkaline medium. The molar absorptivity of the formed dye is 6.620×103 l.mol-1. cm-1 at λ max 510 nm and Beer's law obeyed within in the range of 10-250 μg of phenylephrine-HCl /25 ml (0.4 – 10 ppm). The colour reaction was highly stable and did not show a significant change in absorbance(within acceptable analytical error) up to 48 h with a relative error +0.31 to +1.07% and a relative standard deviation of ±0.95 to ±3.09%, depending on concentration level. The method has been applied successfully to the determination of phenylephrine-HCl in pharmaceutical preparation (nose drop) . | ||
| Keywords | ||
| Phenylephrine; aminobenzothiazole; diazo; Coupling; spectrophotometry | ||
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