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Spectrophotometric Determination of Chlorocresol via Nitrosation Reaction – Application to Pharmaceutical Preparations (Creams) | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 20, Issue 6, 2009, Pages 66-73 PDF (0 K) | ||
| DOI: 10.33899/rjs.2009.39987 | ||
| Authors | ||
| Widad E. Hassan; Nief R. Ahmed | ||
| Abstract | ||
| A spectrophotometric method for the determination of pure chlorocresol and in a number of its pharmaceutical preparations (creams) has been developed that offers advantages of simplicity, sensitivity and stability. The proposed method was based on the formation of a nitroso derivative of chlorocresol. The colored product have maximum absorption at 424 nm. Beer's law is obeyed over the concentration range of (2-26) ppm, with a molar absorptivity of 0.417×104 l.mol-1.cm-1. Relative standard deviation of the method was better than ±1.8% and the average recovery was 99.2%. The proposed method has been successfully applied to the determination of chlorocresol in pure form and in pharmaceutical preparations (creams). | ||
| Keywords | ||
| Chlorocresol; Spectrophotometry; Nitrous acid | ||
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