A. Hussein, R., F. Ghedan, A., K. Kalil, S., H. Jafar, T., A. H. Al-amiry, A., Al-Deen M. Kadhim, H., K. Al-Majedy, Y., T. Tawfeeq, A., A. Ali Al-Hilli, Z. (2011). Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines. , 4(2), 5-16.
Rasha A. Hussein; Aseel F. Ghedan; Saba K. Kalil; Teeba H. Jafar; Ahmmad A. H. Al-amiry; Husam Al-Deen M. Kadhim; Yasmien K. Al-Majedy; Amer T. Tawfeeq; Zaid A. Ali Al-Hilli. "Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines". , 4, 2, 2011, 5-16.
A. Hussein, R., F. Ghedan, A., K. Kalil, S., H. Jafar, T., A. H. Al-amiry, A., Al-Deen M. Kadhim, H., K. Al-Majedy, Y., T. Tawfeeq, A., A. Ali Al-Hilli, Z. (2011). 'Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines', , 4(2), pp. 5-16.
A. Hussein, R., F. Ghedan, A., K. Kalil, S., H. Jafar, T., A. H. Al-amiry, A., Al-Deen M. Kadhim, H., K. Al-Majedy, Y., T. Tawfeeq, A., A. Ali Al-Hilli, Z. Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines. , 2011; 4(2): 5-16.

Novel Synthetic 3-Amino-2-Methylquinazolin-4(3H)- one (L) Induce Apoptosis and Modulate Antioxidant Enzyme Activity in Some Cancer Cell Lines

Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 4, Issue 2, 2011, Pages 5-16
Authors
Rasha A. Hussein; Aseel F. Ghedan; Saba K. Kalil; Teeba H. Jafar; Ahmmad A. H. Al-amiry; Husam Al-Deen M. Kadhim; Yasmien K. Al-Majedy; Amer T. Tawfeeq; Zaid A. Ali Al-Hilli
Abstract
A quinazoline ring possess interesting biological activities, we study the combined cytotoxic activity, induction of
apoptosis and antioxidant enzyme modulation of new synthetic aquinazoline compound in several cancer cell lines.
This compound is 3-amino-2-methylquinazolin-4(3H)-one (L), it was synthesized in the laboratories of Department of
Applied Science - University of Technology – Iraq. Its showed potent cytotoxic and growth inhibition effect on all cancer
cell lines tested. Cells death was due to the induction of apoptosis through modulation of superoxide dismutase (SOD),
glutathione S transferase (GST) and glutathione (glutathione L-glutamyl-L-cysteinylglycine, GSH). These results indicate
that this compound has desirable drug-like properties; it’s of great significance to understand its full anti-proliferative
mechanism.
Keywords
Quinoline; Anti Oxidant enzyme; Apoptosis
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