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Effects of some Fertility Activating Drugs on Histology and Biochemistry of Ovaries of White Rats | ||
| Rafidain Journal of Science | ||
| Article 3, Volume 20, Issue 7, 2009, Pages 28-47 PDF (0 K) | ||
| DOI: 10.33899/rjs.2009.40051 | ||
| Authors | ||
| Likaa H. Al-Dulaimi; Muna H. Jankeer; Janan H. Abdul-Fattah | ||
| Abstract | ||
| The present study included monitoring and diagnosis of tissue changes in polycystic ovary among white adult female rats, which were exposed to continuous light with an intensity of 350 lux/m2 for 14 weeks. These changes were a number of identifying cystic structures of various sizes, the absence of corpus luteum, congestion of blood vessels and ovarian hyperplasia. The study also investigated the influence of two fertility-activating drugs, as clomiphene citrate 1.6 mg/ kg of body weight for one dose estrus stage, metformin 300 mg/ kg of body weight daily. Each of the drugs was used alone or together were given for different periods 4, 8, and 12 weeks. The highest histological change were found when using them together. While no significant tissue changes were observed when using metformine alone. But the treatment with clomiphene citrate alone resulted in medium tissue changes, and were less when combining the two drugs together. The most important changes are fibrosis ovarian follicle cysts, hyperplasia in the cortex and medulla as well as the congestion of blood vessels in addition to an increase in the number of corpora lutea when they are in different atretic stages. The study also included the estimation of concentration of malondialdehyde and glutathione in the polycystic ovary tissue exposed to continuous light. It was found that there was a significant increase in the concentration of malondialdehyde and a significant decrease in the concentration of glutathion. In addition to that, the influence of clomiphene citrate and metformin drugs separately, or together, to estimate the concentrations of malondialdehyde and glutathion in adult female ovary tissues was also investigated. Malondialdehyde concentration was high, while glutathion concentration was low when combining the two drugs. The same results were obtained in all drug treatments and their increase over different periods of time, except for the groups, which were treated with metformin. | ||
| Keywords | ||
| Polycystic ovary syndrome; Clomiphene Citrate; metformin | ||
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