H. Ali, P., Husain, J., Hashim, I. (2010). STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE. , 13(2), 63-68.
Perry H. Ali; Jinan Husain; Iman Hashim. "STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE". , 13, 2, 2010, 63-68.
H. Ali, P., Husain, J., Hashim, I. (2010). 'STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE', , 13(2), pp. 63-68.
H. Ali, P., Husain, J., Hashim, I. STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE. , 2010; 13(2): 63-68.

STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE

Journal of Al-Nahrain University - Science
Article 1, Volume 13, Issue 2, 2010, Pages 63-68
Authors
Perry H. Ali; Jinan Husain; Iman Hashim
Abstract
We have studied for the first time in Iraq, the effect of aspegic and paracetamol on the activity
of creatine kinase in the sera of 25 premenopausal health women our results revealed that in
the presences of increasing concentrations of aspegic and paracetamol the activity of creatine
kinase is inhibited and the inhibition is concentration dependant and independent respectively.
The kinetic parameter of creatine kinase was measured (Vmax= 133.3.00 IU/L,
Km=(2.13 } 0.2 mM).Aspegic act as reversible competitive inhibitor for CK(150 } 3.3 IU/L ,
Km= 2.4 } 0.4mM) and paracetamol act as reversible uncompetitive inhibitor for creatine kinase
(87.72 } 2.1 IU/L, Km=2.02 } 0.33 Mm).
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