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Spectrophotometric Determination of Mefenamic Acid in Pharmaceutical Preparations Via Arsenazo III – Cerium (III) Reaction* | ||
| Rafidain Journal of Science | ||
| Article 2, Volume 20, Issue 1, 2009, Pages 8-21 PDF (0 K) | ||
| DOI: 10.33899/rjs.2009.40249 | ||
| Authors | ||
| Lena S.Awadis; Nabeel S. Othman | ||
| Abstract | ||
| A sensitive indirect spectrophotometric method is proposed for determining mefenamic acid in pure form and in its pharmaceutical preparations. The method is based on oxidation-reduction reaction between mefenamic acid and cerium (IV) ion, and subsequent Ce(III) reaction with arsenazo (III) reagent in acidic medium to produce a greenish-blue complex which is stable, water soluble and has a maximum absorption at 654 nm with a molar absorptivity of 1.731105 l.mol-1.cm-1. Beer’s law is obeyed in the concentration range from 1 to 10 g mefenamic acid in a final volume of 25 ml. The proposed method has been applied successfully to determine mefenamic acid in pharmaceutical preparations. | ||
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