D.S, B., Suzan Mohammed Elian, D., Hayder Hamed Abed, D., M.Sc, , D.S, B., D, P., D, P., Ammar A. Alsa, D., M.Sc, , ady, , D.S, B. (2007). Evaluation of Ciprofloxacin In saliva For the Healthy Volunteers. , 4(2), 144-151.
B. D.S; Dr. Suzan Mohammed Elian; Dr. Hayder Hamed Abed; M.Sc; B. D.S; Ph. D; Ph. D; Dr. Ammar A. Alsa; M.Sc; ady; B. D.S. "Evaluation of Ciprofloxacin In saliva For the Healthy Volunteers". , 4, 2, 2007, 144-151.
D.S, B., Suzan Mohammed Elian, D., Hayder Hamed Abed, D., M.Sc, , D.S, B., D, P., D, P., Ammar A. Alsa, D., M.Sc, , ady, , D.S, B. (2007). 'Evaluation of Ciprofloxacin In saliva For the Healthy Volunteers', , 4(2), pp. 144-151.
D.S, B., Suzan Mohammed Elian, D., Hayder Hamed Abed, D., M.Sc, , D.S, B., D, P., D, P., Ammar A. Alsa, D., M.Sc, , ady, , D.S, B. Evaluation of Ciprofloxacin In saliva For the Healthy Volunteers. , 2007; 4(2): 144-151.

Evaluation of Ciprofloxacin In saliva For the Healthy Volunteers

MUSTANSIRIA DENTAL JOURNAL
Article 1, Volume 4, Issue 2, 2007, Pages 144-151
Authors
B. D.S; Dr. Suzan Mohammed Elian; Dr. Hayder Hamed Abed; ; B. D.S; Ph. D; Ph. D; Dr. Ammar A. Alsa; ; ; B. D.S
Abstract
The use of antibiotics as an adjunctive therapy in the treatment of periodontal diseases is of special interest to dental practitioners. In addition to using an appropriate antibacterial agent, clinicians may find it useful to determine the local and systemic concentrations of antibiotics in infected periodontal sites to reduce the levels of bacteria. The purpose of this study is the determination of the ciprofloxacin concentration in saliva; as well as investigates the efficiency of triethylamine and acetonitrile mobile phase in separation of ciprofloxacin in saliva.
Ten Subjects were given orally a single dose of 500-mg. ciprofloxacin, then 0.5 ml saliva samples were collected into centrifuge tubes (0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, and 24 hrs) after dosing, samples were centrifuged and the separated were injected to HPLC using triethylamine and acetonitrile mobile phase after adjacent the pH at 3.0 ± 0.1 with phosphoric acid at flow rate 1.5 ml/min.
Ciprofloxacin tablets used in this study within the specification and meet the USP requirements in weight variation, disintegration time, dissolution and assay. The obtain result from HPLC method recorded saliva concentration of ciprofloxacin within one day run ranged from 0.062 to 2.0298 mg. / L while day to day run from 0.071-2.030 mg/L. The other pharmacokinetic parameters are: the mean concentration of ciprofloxacin 4.233 μg/ml, C max 3.285, AUC 0-∞ 20.388 μg. h/ ml, and T max 1.203.
The results of this clinical study show that the detection of ciprofloxacin in saliva represents the distribution of the drug in saliva and indicated the suitability for ciprofloxacin in dentistry treatments, and The HPLC method provided successful method for mentoring the ciprofloxacin in saliva with a detection limit reach 1.2 ng/ ml. The analysis method are sensitive, reproducible, low coast and efficient for low concentration
Keywords
Key Word; Bioavailability of ciprofloxacin; saliva; Concentration of ciprofloxacin in saliva
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