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New Synthesis of Imide-Amide Cephalexine as Novel Drug Polymers | ||
| Journal of College of Education | ||
| Article 1, Volume 0, Issue 5, 2017, Pages 381-396 | ||
| Authors | ||
| Firyal M.A; Alaa K. Jabbar; Aseel K.M | ||
| Abstract | ||
| A new drug polymers were synthesized from reaction of cephalexine with thionyl chloride to cephalexinoyl chloride [A1], the cephalexinoyl chloride was reacted with ammonia to form imide-diamine compound [A2]. The last compound condensed with some acidic anhydride such as (maleic or methylnadic anhydride). The two types of polymerswere obtained [A3, A4], the [A3, A4] drug polymers were characterized using FTIR, UV-visible spectroscopy, the intrinsic viscosities were studied at 30oC using Ostwald viscometer. The percentage of swelling was calculated through one day. The Controlled drug release was studied at 37oC at different pH values, the thermal analysis was performed on imide - amide drug polymers. | ||
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