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Some morphological and histological malformation induced of Relief drug on liver and kidney of adult rabbit | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 1, 2012, Pages 92-99 | ||
| Author | ||
| Aziz khalidhameed | ||
| Abstract | ||
| This study was desined to evaluate the morphological change and histological malformation for therapeutic and over therapeutic doses of Relief drug in liver and kidney of the rabbit . Nine rabbits were used in this study and divided in to three groups , each group consis of three rabbit first group was used as acontrol group , second group was treated therapeutic dose at adose 10.7 mg/kg/day of the drug . third group was treated with over therapeutic dose atadose 21.4 mg/kg/day of the drug seven days for each dose the groups were given the drug orally inside the esophagus by using gavage that consist of delicate bent or curved tube. In this study liver and kidney were taken in the results reveal morphological changes in histological malformation disparate in their stringency according to concentration in duration of the dose , these changes in direct proportion forward with the concentration and duration of the doses , these tissues changes includes degeneration, cells swelling , histolysis and necrosis of the tissues , in general severe hemorrhage happened in the damaged cells regions, in the damaged glomeruli of the kidney and hepatocytes cells of the liver . The therapeutic dose second dose 10.7 mg/kg/day was the less effective while the over therapeutic dose (21.4 mg/kg/day) was most effective. | ||
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