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Microwave synthesis of some new heterocyclic compounds containing seven – Membered rings ( 1, 3 – Oxazepine ) | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 1, 2012, Pages 147-158 | ||
| Author | ||
| Abed M. Daher Al-Jibory | ||
| Abstract | ||
| Benzoic acid hydrazide, 4 – hydroxybenzoic acid hydrazide, and isozon, have been reacted with aromatic aldehyds ( 3 – chlorobenzaldehyde, 4 – nitrobenzaldehyde, benzaldehyde, and furferal, 4 – N, N – dimethylbenzaldehyde, 4 – aminobenzaldehyde ) to prepare a new hydrazon compounds ( 1 – 10 ), which have been reacted with phthalic anhydride by Microwave technique, through cycloaddition reaction by the concerted mechanism, to obtained the new ( 1, 3 – Oxazepine ) compounds ( 11 – 20 ). The Microwave technique used to get a green chemistry and short time through any reaction completed by some minutes while this reaction contained some hours in conventional method, Microwave method economic in chemical materials and place and approaches. The prepared hydrazon compounds were identified by melting point and FT. I.R. and the new (1, 3 – Oxazepine) compounds (11, 12, 13, 15, 18, 19) were identified by (1H – NMR, 13C – NMR) was used to support the structure of this compounds and the results are in a good agreement with the proposed structures assigned of the synthesized compounds which can be used anti bacterial and anti fungus, so it used as presynaptic reuptake and anti cancer disease. | ||
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