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A DEVELOPED SPECTROPHOTOMETRIC DETERMINATION OF AMOXICILLIN FORMS VIA CHARGE- TRANSFER REACTION WITH METOL | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 10, Issue 2, 2007, Pages 1-6 | ||
| Authors | ||
| ; | ||
| Abstract | ||
| A spectrophotometric method for determination of amoxicillin (AMX) in pure and pharmaceutical formulations is described. The proposed method involves the use of metol (N-methyl-p-hydroxy aniline) as a chromogenic reagent.The drug produce a bluish-green coloured soluble charge- transfer complex with metol in the presence of potassium persulphate in alkaline medium. The coloured product is measured at λmax 620 nm . Under the optimum conditions calibration graph was observed a linear from 5-60 μg ml-1 AMX and with correlation coefficient not less than 0.9994 which was suitable for the quantitative determination of the drug.The molar absorbitivity was 2.726×103 L.mole-1.cm-1,and sandell sensitivity of 0.1538 μg cm-2 . The relative standard deviation of the proposed method was 0.25-2.44% depending on the concentration of AMX. The proposed method was successfully applied to the determination of AMX in injections and capsules. | ||
| Keywords | ||
| Spectrophotometric; Amoxicillin; metol; charge; transfer reaction | ||
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