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Effect of PolysaccharideAntigens Extracted from Proteus mirabilis on immune response in mice | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 1, Issue 2, 2009, Pages 12-18 | ||
| Abstract | ||
| Department of Pathological analysis , College of Science, Kufa University Proteus mirabilis is a common pathogenic agent in respiratory and urinary tract infections. To evaluation of the effectiveness of polysaccharide antigen isolated from Proteus mirabilis on induce humeral & cell mediated immunity were isolated from urine, wounds,burns, ear, sputum and eye in( 28.8 , 23.7 , 22 , 18.6 , 5.1 , 1.7)% respiratory from patients referred to the consultants clinics in Al-Hakim general hospital in Najaf covernorate .Pm1isolate was selected in this study (which have stable antigenicity &typical biochemical characters) from polysaccharide antigen extraction.Mice immunized daily administration of( 50,100) µg/ml of (PmAg) intramuscular dose for 12 days.The ability of these antigens for immunization were determined by certain parameters included :toxicity,Arthus& delayed type hypersensitivity test (DTH) ,plaque forming cells assay. PsAg had no effect on peritoneal macrophages and lymphocyte viability at concentration (50 ,100) µg/ml .Averages of Arthus reaction & TH were significantly increased as compared with control group at (P<0.01) High significant differences have been noticed in the | ||
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