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Synthesis of Barbiturate Derivatives from Imines | ||
| Journal of Research Diyala humanity | ||
| Article 1, Volume 0, Issue 39, 2017, Pages 1-10 | ||
| Author | ||
| Ahlaam Jassim Zaier | ||
| Abstract | ||
| Barbiturates were prepared involving the reaction of aromatic Schiff bases with benzoyl chloride to give N-[α-chloro-α-dimethylaminobezyl]-N-aryl-benzanilide. The reaction of the latter with diethylmalonate in basic media to give N-[α-diethylmalonyl-α-p-dimethylaminobenzyl]-N-aryl-benzanilide. The latter condense with urea in basic media afforded derivatives of barbiturate which known to act as hypnotics. | ||
| Keywords | ||
| Barbiturates; hypnotics | ||
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