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Some Applications of High Performance Liquied Chromatography -Determination of Trimethoprim | ||
| Rafidain Journal of Science | ||
| Article 1, Volume 19, Issue 5, 2008, Pages 1-9 PDF (0 K) | ||
| DOI: 10.33899/rjs.2008.41401 | ||
| Author | ||
| Hana Sh. Mahmood | ||
| Abstract | ||
| A simple, fast and precise high performance liquid chromatographic method for the assay of trimethoprim in the presence of sulphamethoxazole has been developed. The procedure is based on using acetonitril: water: acetic acid in the ratio of 30:69.9:0.1 (v : v : v) as a mobile phase, flow rate (1ml/min.) and uv detector (254nm.).Each analysis required no longer than 10 minutes. the detector responses were linear in the range of 0.05-120µg/ml for trimethoprim with a relative standard deviation of 0.49-0.971% and a relative error of 1-2.5% . The proposed method was also applied satisfactorily to the pharmaceutical preparation. | ||
| Keywords | ||
| trimethoprim; High performance liquid chromatography; UV detector; Pharmaceutical preparation | ||
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