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Direct Determination of Prednisolone by Derivative UV Spectroscopy | ||
| Rafidain Journal of Science | ||
| Article 5, Volume 19, Issue 5, 2008, Pages 38-46 PDF (0 K) | ||
| DOI: 10.33899/rjs.2008.41452 | ||
| Author | ||
| Nada B. Shareef | ||
| Abstract | ||
| UV Derivative spectra were used for the direct quantitative determination of Prednisolone in absolute ethanol, the quantification was accomplished according to the integrated area under the peaks. The zero-order spectrum of Prednisolone show an absorption band at = 242nm, with molar extinction coefficient max = 13770 lit. mol-1. cm-1, the determination range was (0.36-50.46) g/ml with R2 =0.9998 and relative standard deviation RSD =1.28 %. The determination ranges were (0.10- 72.09) g/ml, (0.36-72.09) g/ml for first and second-order derivatives respectively with R2 = 0.9999, 0.9998 and RSD = 1.53%, 2.55% respectively. This indicate a more sensitive and accurate results as compared with the zero-order method. These methods were applied for the direct determination of the PRISOLONE tablets. | ||
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