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Indirect Spectrophotometric Method for Determination of Bromhexine-Hydrochloride in Pharmaceutical Preparations | ||
| Rafidain Journal of Science | ||
| Article 3, Volume 19, Issue 3, 2008, Pages 16-27 PDF (0 K) | ||
| DOI: 10.33899/rjs.2008.41487 | ||
| Authors | ||
| Shilan A. Omer; Nabeel S. Othman | ||
| Abstract | ||
| A sensitive indirect spectrophotometric method is developed for the determination of bromhexine-HCl in pure and dosage forms. The method is based on the oxidation of bromhexine-HCl with iron(III) in acidic medium, then reaction of iron(II) with 1,10-phenathroline to produce a ferroin complex which is water-soluble, stable, and has a maximum absorption at 510 nm against the reagent blank with a molar absorptivity of 3.51×104 l.mol-1.cm-1. Beer’s law is valid over the concentration range of 10 to 220g bromhexine-HCl in a final volume of 25 ml. The proposed method has been applied successfully to determine bromhexine-HCl in different pharmaceutical preparations. | ||
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