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Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients | ||
| Baghdad Science Journal | ||
| Article 1, Volume 7, Issue 3, 2010, Pages 1166-1173 | ||
| Author | ||
| Shatha Abd AL- Wadood Al-Shammaree | ||
| Abstract | ||
| Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy. The results indicated that ADA specific activity increased significantly (P<0.05), while 5´-NT and AMPDA specific activity decreased significantly (P<0.05) in ovarian cancer patients before surgery in comparison with those of their corresponding control women and benign tumors groups. When the activities of these enzymes were measured after chemotherapy, a significant decrease (P<0.05) in ADA activity, and a significant increase (P<0.05) in 5´- NT and AMPDA activities were found in comparison with those before surgery. | ||
| Keywords | ||
| Adenosine deaminase; Nucleotidase; AMP; ovarian cancer; chemotherapy | ||
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