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PREPARATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NEW (2-ISOXAZOLINE) AND (2-PYRAZOLINE) DERIVATIVES FROM AROMATIC HETROCYCLIC CHALCONES | ||
| AL-TAQANI | ||
| Article 1, Volume 19, Issue 2, 2006, Pages 1-6 | ||
| Author | ||
| Rita S. Adam | ||
| Abstract | ||
| In this paper new series of (2-Isoxazoline) VIa-c and (2- Pyrazoline) V a-c were prepared by condensation of aromatic Hetrocyclic Chalcones IIIa-c with hydroxylamine hydrochloride and phenyl hydrazine using glacial acetic acid .The synthesized compounds IIIa-c, VIa-c, V a-c were characterized by using FT/IR spectra, C.H.N. analysis. The validity of the expected chemical compounds to the prepared compounds in this search was obvious from FT/IR spectra and C.H.N. results. It also deals with study of the biological activity of the prepared compounds (VIa-c), (V a-c) which showed biological activity against (Escherichia coli and Staphylococcus aureus) in comparison to the aromatic Hetrocyclic Chalcones IIIa-c. The verification between (2-Isoxazoline) and (2- Pyrazoline) is in their abilities to inhibit the growth of gram positive and gram negative bacteria. | ||
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