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INHIBITIONAL CHOLINESTERASC ENZYME ACTIVITY BY NEW DERIVATIVES OF PHENINDIONE | ||
| AL-TAQANI | ||
| Article 1, Volume 18, Issue 1, 2005, Pages 44-56 | ||
| Author | ||
| Falah S.D. AL-Fartusie | ||
| Abstract | ||
| This study was designed to show the effects of new derivatives of phenindione on the activity of ChE in sera. All compounds studied demonstrated inhibitory effects on the enzyme activity and these effects are increased with increasing the concentrations of the compounds. The compound 2-(3-Chloro propanoyl)-2-phenyl-1,3-indandione has the highest ability to inhibit ChE of other compounds. Kinetic properties of these inhibitors reveal that compounds (3,6,8 and 10) cause mixed type of inhibition, compounds (1,4,7 and 9) act as competitive inhibitors, compound (5) acts as a non-competitive inhibitor and compound (2) behaves as an un-competitive inhibitor. The mechanism of action of these types of compounds acting as inhibitors to the ChE is suggested. | ||
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