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A Comparative Study of Three different Commercial brands of Glibenclamide Preparations | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 2, Issue 3, 2005, Pages 318-323 | ||
| Authors | ||
| Dhaher Jamel S. Al-habbo; Farag M Abdulla; Younise A KH. Al-Aubaidi | ||
| Abstract | ||
| This study aimed to assess the efficacy and the serum levels of three commercial brands of glibenclamide on diabetic patients. The design of study was case control and triple blind study of the serum level and the hypoglycemic efficacy of three commercial brands of glibenclamide on ninety patients with diabetes mellitus. The study was performed at AL-Wafa Center for the treatment of Diabetes mellitus and at Nenava Factory for Pharmaceuticals, during the period from August 2002 to February2003. Ninety patients with Diabetes mellitus, 48 female and42 male patients, and their ages ranging from 31 to 80 years and the mean were 54.07 years. To compare the three brands of glibenclamide and to test their hypoglycemic effect, Analysis of variance (ANOVA) test were utilized. Furthermore to determine which one of them is the most statistically significant Duncan’s Multiple Range Test were utilized. To determine which one of them has the highest serum level in two hours, the analysis of variance for the three samples was used. The analysis of variance indicates that there were statistically significance differences between the three groups. The calculated (F) is larger than the tabulated (F) at the level of 0.05 and at 0.01 level). Duncan's Multiple Range Test indicates that the GLIBESYN brand is the most potent hypoglycemic brand among them. For the serum level of the three brands, the analysis of variance indicates that there was no statistically significant difference between the serum levels of the three brands. This study ascertains the need of wide range of determination of the efficacy of the other hypoglycemic drugs. The High Performance Liquid Chromatography with fluorescence detection (HPLC) is very easy and very sensitive test and should be used more regularly. | ||
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