The Effects of Proteinous Compound and Nonproteinous Fractions, Isolated from Cold Aqueous Extract of ( Cinnamomum cassia ) Bark on the Levels of Glucose and Lipoproteins on  Blood Serum of Mice

S . Ahmed, Israa; A . Mustafa, Layla

doi:10.33899/rjs.2007.42711

	The Effects of Proteinous Compound and Nonproteinous Fractions, Isolated from Cold Aqueous Extract of ( Cinnamomum cassia ) Bark on the Levels of Glucose and Lipoproteins on Blood Serum of Mice
Rafidain Journal of Science
Article 8, Volume 18, Issue 4, 2007, Pages 72-87 PDF (0 K)
DOI: 10.33899/rjs.2007.42711
Authors
Israa S . Ahmed; Layla A . Mustafa
Abstract
One proteinous component had been isolated from gel filtration chromatograghy of the full saturated precipitate produced by ammonium sulphate of the aqueous extract of the Cinnamomum cassia bark. The apparent molecular weight of the isolated component was found to be (6558) Dalton using gel filtration chromatograghy and (6732) Dalton using sodium dodecyl sulphate polyacryl amide gel electrophoresis. The results showed that the cold crude aqueous extract non- proteinous extract and proteinous component isolated from aqueous extract were lowered glucose level using a dose of 100 mg/kg weight. The percent decrease were (38%, 21% and 25%) respectively in normal mice, where as in diabetic mice, the proteinous component isolated from aqueous extract was the most effective in lowering glucose level using a dose of 100 mg/kg body weight where the percent decrease was 85%. Finally, the crude aqueous extract and proteinous component isolated from the cold aqueous extract showed a significant decrease in the level of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL-C) and low density lipoprotein (LDL-C) in normal mice. However, in diabetic mice, the cold non- proteinous extract was the most effective in lowering TC, TG, VLDL-C, LDL-C and HDL-C levels.

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