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Status of Total L-Carnitine Level in the Seminal Plasma of Iraqi Infertile and Fertile Men: Correlation Study with Semen Quality | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 10, Issue 1, 2011, Pages 78-80 PDF (0 K) | ||
| Author | ||
| Zainab N.H. Anbar | ||
| Abstract | ||
| ABSRACT: BACKGROUND: Carnitine is highly concentrated in the epididymis and Spermatozoa, where it may serve as an intramitochondrial vehicle for theAcyl group, a substrate of energy production. This study is aimed to determine any correlation between male infertility and semen quality with Concentration of L- carnitine in human seminal plasma. OBJECTIVE: This case-control study performed at the Institute of Embryo Research and Infertility, University of Al-Naharin, Baghdad. Semen samples of 40 infertile men (azoospermia, n=12, oligoasthenozoospermia, n=16, teratozoospermia, n=12) and 12 fertile men controls were collected. METHODS: The level of total L- carnitine in seminal plasma was determined by high performance liquid chromatography and the results correlated with sperm parameters as sperm count, motility and morphology. RESULTS: The level of L-carnitine was significantly reduced in infertile male groups; azoospermia, oligoasthenozoospermia and teratozoospermia in comparison with that of fertile male controls (P< 0.045, P< 0.023 and P< 0.04; respectively). There was a borderline significant positive correlation between the seminal L-carnitine and the sperm count in fertile group(r=0.63, P< 0.51). CONCLUSION: The results of this study indicated the significance of determination of seminal plasma L-carnitine in evaluation of infertility in men and the importance of recognition of those infertile male who are benefit from administration of carnitine supplement. | ||
| Keywords | ||
| carnitine; seminal plasma; male infertility | ||
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