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The Role of IL-1 and Tumor Necrosis Factor-α in Pathogenesis of Rheumatoid Arthritis | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 10, Issue 2, 2011, Pages 161-165 PDF (0 K) | ||
| Authors | ||
| Eman Sh.Al-Obeidy; Shatha F. Abdullah | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Rheumatoid Arthritis (RA) is a common chronic inflammatory and destructive arthropathy that cannot be cured.Interlukin-1 (IL-1), IL-6 and tumor necrosis factor (TNF- α) are the key cytokines that drive inflammation in the disease. OBJECTIVE: The study was established to shed light on the possible role of IL-1 and TNF- α in pathogenesis of RA. PATIENTS AND METHODS: Rheumatoid Factors (RF),TNF-α and IL-1 were detected by Enzyme-Linked Immunosorbent Assay (ELISA) .C-reactive protein(CRP) on the other hand has been detected by using latex agglutination kit in the serum of 50 Iraqi patients with RA in comparison with 50 healthy individuals. RESULTS: Significant high levels of IL-1and TNF- α were observed in RA patients sera with P-value ( 0.04 and 0.001) respectively compared to healthy control group, in addition a positive linear association was found between the concentration of IL-1and TNF- α and CRP with P-value ( 0.05 and 0.001) respectively. CONCLUSION: IL-1and TNF- α play a role in pathogenesis of RA | ||
| Keywords | ||
| Rheumatoid Arthritis; interlukin; tumor necrosis factor | ||
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