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The Clot-lysis Effect of Selective α1-Adrenoceptor Antagonist in Vitro Model Associated with High Peroxynitrite Level | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 10, Issue 2, 2011, Pages 269-272 PDF (0 K) | ||
| Authors | ||
| Marwan S.M. Al-Nimer; Ali Ismail A. AL-Gareeb; Hayder M. Al-Kuraishy | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Alpha1-adrenoceptor blocking agents showed several effects beyond their action on the vascular smooth muscles. They improve the lipid profile and inhibit the aggregation of blood platelets. OBJECTIVE: To investigate the clot-lysis effect of selective α1-adrenoceptor antagonists and its relation to peroxynitrite level in vitro experimental model. MATERIALS AND METHODS: Venous blood samples obtained from ten healthy subjects. To each pre-weighed clot, 100 μL of either distilled water as a negative control, prazosin (10 μg), terazosin (20 μg) and alfuzosin (25 μg) were added. Peroxynitrite level was measured in sera and sangious fluid that formed after clot-lysis. RESULTS: Prazosin, terazosin and alfuzosin,in order, significantly reduced the clot weight up to 3.7%. Peroxynitrite level in sangious fluids was higher in treated groups than that of negative control or sera levels. CONCLUSION: α1-adrenoceptor antagonists induced clot-lysis effect. This effect is associated with generation peroxynitrite | ||
| Keywords | ||
| clot; lysis; adrenoceptor antagonist; peroxynitrite | ||
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