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Immunohistochemical Expression of Matrix Metalloproteinase-9 in Jaws and Long Bones Osteosarcomas | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 10, Issue 3, 2011, Pages 403-407 PDF (0 K) | ||
| Authors | ||
| Bashar Hamid Abdullah; Luay Edward Alkhuri; Khitam Razzak Alkhafaji; Salam Nihad Jawad | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Matrixmetalloproteinases (MMPs) are a class of matrix basement membrane degrading enzymes which were shown to be associated with metastases in several human tumors. OBJECTIVE: This study is aimed to investigate the potential effect of MMP-9 in imparting the frequently reported different behavioral pattern between jaws and long bones osteosarcomas. METHODS: Tissue blocks of ten cases of jaws osteosarcomas and another ten of long bones osteosarcomas were collected and stained immunohistochemically with monoclonal antibodies to MMP-9. RESULTS: The majority of cases (70%) were positive for MMP-9 expression which indicates a role in tumor spread, however; there was no significant difference between the sites. CONCLUSION: The study indicates that MMP-9 is probably not involved in the biologic differences between jaws and long bones osteosarcomas | ||
| Keywords | ||
| jaw osteosarcoma; matrixmetalloproteinase | ||
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