Indirect  Assessment of Endothelial   Function in Patients  with   Hypertension and Diabetes Mellitus

T. Al-Gailani, Bassam; Seyhood Al-Shujiri, Gafil; G. Hamed, Kahtan

	Indirect Assessment of Endothelial Function in Patients with Hypertension and Diabetes Mellitus
Medical Journal of Babylon
Article 1, Volume 2, Issue 1, 2005, Pages 50-60
Authors
Bassam T. Al-Gailani; Gafil Seyhood Al-Shujiri; Kahtan G. Hamed
Abstract
Thirty eight participants (27 men, 11 women) with age between 40-60 years were divided into 3 groups. Group I: Includes 13 healthy subjects. Group II: Includes 13 patients with essential hypertension. Group III: Includes 12 patients with type 2 diabetes mellitus. Using high-resolution ultrasound, brachial artery diameters at rest, during reactive hyperaemia (endothelium-dependent dilation] and after sublingual glyceryl trinitrate (GTN) application (endothelium-independent dilation) were measured. The percentage increase of brachial artery diameter after reactive hyperemia (flow-mediated diltation% or FMD%) in control subjects was 8.85 ± 0.25% while it was found to decrease significantly (P<0.0001) in hypertensive and diabetic patients by 60% and 67% respectively. Furthermore, the percentage increase of the brachial artery diameter after glyceryl trinitrate (glyceryl trinitrate-induced dilatation% or GTNID %) in control healthy subjects was 14.41 ± 0.81%. The GTNID% was found to decrease significantly (P < 0.006)by 25% in hypertensive patients. No significant GTNID% change was found in diabetic patients. The antioxidant-oxidant ratio index (RI)of the measured biochemical parameters was significantly lower in hypertensive patients (by 50%)and even more lower in diabetic patients (by 84%) The antioxidant-oxidant RI was found to be significantly and posiviely correlated with FMD% and GTNID% in diabetic patients only.

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