A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with â–Thalassemia

M.  Al-Rubaei, Zeinab; MJ Al-Shammaa, Nawal; M. Malik, Emad; M. Malik, Ali

	A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with â–Thalassemia
Iraqi Journal of Pharmaceutical Sciences
Article 1, Volume 19, Issue 2, 2010, Pages 19-23
Authors
Zeinab M. Al-Rubaei; Nawal MJ Al-Shammaa; Emad M. Malik; Ali M. Malik
Abstract
The aim of the present research is to study different protein fractions in sera of children and adolescent with â –thalassemia major and minor and to compare the results with that of healthy control.One hundred fifty children and adolescents were enrolled in this study,including 50 patients with â- thalassemia major , 50 patients with â- thalassemia minor as pathological control group and another apparently 50 healthy individuals as a control group. The age of all studied groups ranged from (4-18)years.Total protein, albumin and immunoglobulins were estimated in sera of all subjects. A Significant decrease was found in the total protein and albumin levels in sera of both major and minor thalassemic patients compared to normal groups. A Significant increase in immunoglobulin levels (IgG, IgM and IgA) was found in the sera of major and minor â-thalassemia patients compared to control.Different protein parts in sera of all subjects were detected using cellulose acetate electrophoresis.The results revealed significant reduction in â- globulin fractions in â- thalassemia major patients compared to the normal and pathological control groups. Significant elevations in م- globulins fractions were observed in both major â- thalassemia and minor â- thalassemia as compared to normal control group. As a Conclusion the alteration in some protein parts occurred which is more obvious in major thalassemia patients compared to the normal and pathological control groups.
Keywords
Protein Parts; Elecrtrophoresis; Thalassemia

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