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Tumor Suppressor Gene( E-Cadherin )and Its Role in Normal and Malignant Cells | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 1, Issue 3, 2004, Pages 0-0 | ||
| Author | ||
| Ali Hassan Al-Timimi | ||
| Abstract | ||
| Tumor suppressor genes (E-cadherin) are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper. | ||
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