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Acute myeloid leukemia: clinical features and follow-up of 115 Iraqi patients admitted to Baghdad Teaching Hospital | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 1, Issue 111, 2012, Pages 1-8 | ||
| Authors | ||
| Alaa F. Alwan; Omar S. Salman; Zedan J. Zedan | ||
| Abstract | ||
| Acute myelogenous leukemia (AML) is a clonal disorder of the bone marrow that is characterized by abnormal proliferation of immature myeloid cells. Patients may have pallor, fatigue, and shortness of breath secondary to anemia; bleeding, bruising, and ecchymosis secondary to thrombocytopenia / coagulation defects; and infections secondary to neutropenia. The treatment of newly diagnosed AML is divided into phases. Induction phase and post-remission chemotherapy. The aim of the study was to determine the clinical and hematological characteristics of patients with de novo AML and to determine the 3 years overall survival. This study was conducted at Baghdad Teaching Hospital/hematology unit from January 2006 till January 2008 inclusive. It included 115 patients with de novo AML. The diagnosis of AML was established in the Teaching Laboratories according to the cytomorphology and criteria of the French-American-British (FAB) classification system. There were 63 males and 52 females with median age of 35 years. Pallor was found in 95 patients (83%), and easy fatigability in 81 patients (70%), while bleeding tendency was present in 84 patients (73%). Splenomegaly was present in 26 patients (23%) and hepatomegaly was found in just 20 patients (17%), while lymphadenopathy at presentation was detected in only 9 patients (8%). The median haemoglobin level, WBC count, platelets and blasts percent were 9 gm/dL, 10 x 109 /L, 75 x 109 /L, and 35% respectively. One hundred eleven patients were given induction chemotherapy, 81 patients (70%) achieved CR, and there was no significant difference between those patients on Midac or 2+5 regimens. The median overall survival was 7 months | ||
| Keywords | ||
| Acute myeloid leukemia; up of | ||
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