Spectrophotometric Determination  of Chlorpromazine-HCI by Charge-Transfer Complex Formation  With some 1t­ acceptors.

	Spectrophotometric Determination of Chlorpromazine-HCI by Charge-Transfer Complex Formation With some 1t acceptors.
Ibn Al-Haitham Journal For Pure And Applied Science
Article 1, Volume 21, Issue 4, 2008, Pages 56-67
Abstract
Two Spectrophotometric methods are presented for the determination of chlorpromazine-HCl in pure and pharmaceutical preparation. The methods are based mainly on charge transfer complexation reaction of the drug as n-donor with either 2, 3- dichloro-5, 6-dicyano-p-benzoquinone (DDQ) or p-chloranilic acid (p CA) as 1t-accepter. The produced colored products are quantified spectrophotometrically at 450 nm and 550 nm in DDQ and p-CA methods respectively. Beer's Law is obeyed in a concentration range of (8 - 50 11g/ml) for complex with DDQ and (10 - 70 11g/ml) for complex with p-CA.The molar absorpitivities are found to be (4.7965 x 10 3 and 1.0516 x 10 3 ) for DDQ and p-CA respectively. The proposed procedures were successfully utilized in the determination of the drug in pharmaceutical preparations. Statistical comparison of the results was performed with regard to accuracy and precision.

Statistics Article View: 189 PDF Download: 95

Spectrophotometric Determination of Chlorpromazine-HCI by Charge-Transfer Complex Formation With some 1t acceptors.