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Application of Trifluoperazine Hydrochloride as a Chromogenic Reagent for Spectrophotometric Determination of Sulphacetamide Sodium – Application to Ophthalmic Preparations | ||
| Rafidain Journal of Science | ||
| Article 11, Volume 17, Issue 7, 2006, Pages 92-103 PDF (0 K) | ||
| DOI: 10.33899/rjs.2006.43679 | ||
| Authors | ||
| Raeeid M. Kadder; Nabeel S. Othman | ||
| Abstract | ||
| A simple, rapid and sensitive spectrophotometric method for the determination of sulphacetamide sodium (SAS) was described. The method based on the oxidative coupling reaction of trifluoperazine hydrochloride (TFP) with SAS using ammonium ceric sulphate (ACS) as oxidizing agent in acidic medium to form a water soluble product, that is stable and has a maximum absorption at 560 nm. Beer’s law is obeyed in a concentration range of 1-22 g.ml-1 SAS with a molar absorptivity of 7.0103 L.mol-1 .cm-1, a relative error of –0.56 to +2.33% and a relative standard deviation of 2.56 to 4.56% depending on the concentration of SAS. The proposed method has been successfully applied to the determination of SAS in various ophthalmic preparations. | ||
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