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Formulation, Stability and Bioequivalency Study of Prepared Salbutamol Sulphate Nebules | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 14, Issue 1, 2005, Pages 65-74 | ||
| Authors | ||
| Alaa A. Abdul; ; Bazigha K. Al; | ||
| Abstract | ||
| Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma .This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin® nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant difference between the formula and ventolin® nebules regarding their pharmacokinetic parameters which include elimination rate constant, elimination t 0.5 and amount of the unchanged drug excreted in urine, 30 min. after administration (p<0.05) . This study may suggest that the prepared formula could be used successfully in the preparation of salbutamol sulphate nebules. | ||
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