I. Khalil, Y., H. Hussain, A. (2008). Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form. , 17(1), 1-6.
Yehia I. Khalil; Ahmed H. Hussain. "Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form". , 17, 1, 2008, 1-6.
I. Khalil, Y., H. Hussain, A. (2008). 'Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form', , 17(1), pp. 1-6.
I. Khalil, Y., H. Hussain, A. Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form. , 2008; 17(1): 1-6.

Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form

Iraqi Journal of Pharmaceutical Sciences
Article 1, Volume 17, Issue 1, 2008, Pages 1-6
Authors
Yehia I. Khalil; Ahmed H. Hussain
Abstract
An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 polymer drug ratio .Besides to that , the results indicated that the release profiles were affected by pH- medium , PVP and EC addition as an enhancer or retardant polymer used respectively. As well as to the method of preparation .
Keywords
Pentoxifylline Sustained Retease; Eudragit RS
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