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Formulation of Alpha Tocopherol Acetate as a PowderDosage Form by Adsorption | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 16, Issue 1, 2007, Pages 18-25 | ||
| Authors | ||
| Yehia I. Khalil; Zena A. Abdulhameed | ||
| Abstract | ||
| Alpha-tocopherol acetate is one of the most important vitamin E derivatives,that were used as antioxidants. Adsorbents like kaolin, magnesium carbonate, and microcrystalline cellulose were used successfully to incorporate oily alpha-tocopherol acetate into an acceptable powder dosage form. The results revealed that microcrystalline cellulose as an adsorbents gave the best results with 50% loading capacity at time, 8 minutes before and after incubation period (3 months at 30C„a), while kaolin and magnesium carbonate have been shown a significant difference before and after incubation. Addition of 1% w/w magnesium carbonate to the kaolin enhanced the loading capacity by decreasing the time of adsorption from 20 to 6 minutes and 47 to 9 minutes before and after incubation respectively. The study indicated that the best adsorbent to be used in case of oral vitamin E toxicity is microcrystalline cellulose while magnesium carbonate could be used in the formulation for their best adsorption effect. | ||
| Keywords | ||
| adsorption; Tocopherol Acetate powder | ||
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