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Phosphodiester Conjugation of Metronidazole and Dexamethasone as Possible Mutual Prodrug | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 15, Issue 1, 2006, Pages 80-85 | ||
| Authors | ||
| Suhair M. Ghani; Muthana D. Saud | ||
| Abstract | ||
| As possible mutual prodrug had been synthesized that contain metronidazole and dexamethazone conjugated through phosphodiester linkage. The rationale for this type of conjugate is to get a prodrug with possible site – specific delivery of its active constituents into the lower parts of the G.I.T. This compound was synthesized by the reaction of dexamethzone – 21 – phosphate with metronidazole to form:(1 – (dexamethazone – 21 – phosphoryl) – metronidazole) This conjugate was performed using dicyclohexylcarbodiimide (DCC) as a condensing agent. The identity of the prepared compound had been confirmed using T.L.C., U.V. spectroscopy, IR spectroscopy and elemental analysis. The partition coefficient for it had also been determined through n – Octanol / water partitioning system. | ||
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