Oil and Aqueous Extracts of Peanut (Arachis hypogaea L.) and Its Cake on Blood Lipid Profile in Rats treated with Hydrogen Peroxide, Saturated Animal Fats and Cholesterol

H. Hameed, Khalid; S. Kallo, Maan

doi:10.33899/rjs.2006.44191

	Oil and Aqueous Extracts of Peanut (Arachis hypogaea L.) and Its Cake on Blood Lipid Profile in Rats treated with Hydrogen Peroxide, Saturated Animal Fats and Cholesterol
Rafidain Journal of Science
Article 1, Volume 17, Issue 13, 2006, Pages 1-16 PDF (0 K)
DOI: 10.33899/rjs.2006.44191
Authors
Khalid H. Hameed; Maan S. Kallo
Abstract
Forty-two albino male adult rats with atherosclerosis induced by 0.5% hydrogen peroxide, 4.69% saturated animal fats and 0.26% cholesterol added to the diet, were used in this study as experimental and biological model. Their body weights ranged between 250-275g and aged 3-4 months. They were divided into seven equal number and identical body weights groups. The first group was a negative control, second group was a positive control (standard group), orally treated with 0.57% Flavostatin /Kg body weight, third and forth groups were orally treated with 300 and 600mg peanut oil extracts/Kg body weight respectively, fifth and sixth groups were orally treated with 120 and 240mg peanut aqueous extracts/Kg body weight respectively, seventh group fed the atherogenic diet containing 10% peanut cake. All groups were fed atherogenic diet (containing animal fats and cholesterol) and treated with 0.5%H2O2 in freshly prepared drinking water daily ad libitum. The experimental period was continued for 15days, in addition to 30days during which the rats were prepared for induction of atherosclerosis by 0.5% H2O2 with drinking water and atherogenic diet. Analysis of variance and Duncan multiple tests showed that, the peanut aqueous extract/Kg rat body weight and 10% peanut cake exerted a significant (p<0.05) decreasing effect on serum total lipids (TL), cholesterol (TC), triglycerides (TG), phospholipids (PL) and the undesirable very low density (VLDL-c) and low density (LDL-c) lipoproteins, atherogenic indices and malondialdehyde content of liver, heart and kidney. On the other hand, they caused increased levels of the desirable high density lipoprotein, while the peanut oil extract caused undesirable increase in serum VLDL-c and LDL-c lipoproteins, TC and TG.

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