S. Al-Ghabsha, T., M. Saeed, A. (2012). Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution. , 5(3), 13-17. doi: 10.37652/juaps.2011.44301
Thabit S. Al-Ghabsha; Amal M. Saeed. "Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution". , 5, 3, 2012, 13-17. doi: 10.37652/juaps.2011.44301
S. Al-Ghabsha, T., M. Saeed, A. (2012). 'Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution', , 5(3), pp. 13-17. doi: 10.37652/juaps.2011.44301
S. Al-Ghabsha, T., M. Saeed, A. Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution. , 2012; 5(3): 13-17. doi: 10.37652/juaps.2011.44301

Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution

Journal of University of Anbar for Pure Science
Article 6, Volume 5, Issue 3, 2011, Pages 13-17    PDF (300.08 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2011.44301
Authors
Thabit S. Al-Ghabsha; Amal M. Saeed*
University of Mosul - College of Education.
Abstract
A simple, rapid and sensitive spectrophotometric method for the determination of
noradrenaline was developed. The method is based on the proton transfer reaction with quinalizarin in
aqueous neutral solution to form a violet product showing maximum absorbance at 560 nm with molar
absorptivity of 6680 l.mol-1.cm-1. The method follows Beer’s law over the concentration range
(5.91×10-6 -5.91×10-5) mol.L-1 The accuracy (average recovery) of the method is 99.72% and the
precision (RSD) of the method is less than 1.5%.The method was successfully applied for the
determination of noradrenaline in pharmaceutical formulation as injection and the results were in a
good agreement with the standard addition procedure.
Keywords
Noradrenaline; Spectrophotometric method; Quinalizarin; Pharmaceutical Formulation
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