Effect of Excessive Levels of Vitamin A on Bone Formation and some Biochemical Parameters in Young Rats

M.  Ahmad, Hadeel

doi:10.33899/rjs.2012.44410

	Effect of Excessive Levels of Vitamin A on Bone Formation and some Biochemical Parameters in Young Rats
Rafidain Journal of Science
Article 5, Volume 23, Issue 4, 2012, Pages 44-54 PDF (0 K)
DOI: 10.33899/rjs.2012.44410
Author
Hadeel M. Ahmad
Abstract
The present study was designed to effect the excessive levels of vitamin A on bone formation and some biochemical parameters in young rats. 18 of albino males young rats were divided into 3 groups it 6 animals each. These included untreated control and two treated groups received orally vitamin A at the doses 330 and 660 IU/g B.W daily for 30 days. Animals were weighted weekly, Blood samples were obtained at specific times for biochemical parameters determination which include alkaline phosphatase activity (ALP), Calcium, Inorganic phosphorus ,magnesium and albumin levels. At the end of the experimental period, rats were anesthetized and killed. The right femur bone were obtained for mineral analysis in bone ash include calcium, magnesium and Phosphorus. The results showed significant decrease in body weights and ALP, calcium, Inorganic phosphorus, magnesium, albumin in the serum of the first and the second groups. More reduction was observed in the second group when compared with the control groups. The mineral analysis of bone ash showed a significant decrease in calcium, magnesium, Phosphorus in the first and the second groups compared with control groups. It was concluded from this study, that excessive levels of vitamin A caused an effect on body weight and defect detection in bone formation of young males rats.
Keywords
vitamin A; vitamin A high dose; bone; Rats

Statistics Article View: 490 PDF Download: 589