Effect of Lead on some Antioxidants and Lipid Peroxidation in Blood of White Male Albino Rats

H. Jankeer, Muna

doi:10.33899/rjs.2012.44411

	Effect of Lead on some Antioxidants and Lipid Peroxidation in Blood of White Male Albino Rats
Rafidain Journal of Science
Article 6, Volume 23, Issue 4, 2012, Pages 55-69 PDF (0 K)
DOI: 10.33899/rjs.2012.44411
Author
Muna H. Jankeer
Abstract
The present study includes the investigation of the effect of lead on some enzymatic, non enzymatic antioxidants and lipid peroxidation in serum of male albino rats Rattus norvegicus aged 2.5-3 months. Fifty male rats were randomly divided into 5 groups (10 rats/ group).The first group: was given standard forage and distilled water (as a drinking water) and considered as control. The second group: was given standard forage and distilled water (as a drinking water) containing 20 mg lead /L. daily for a period of 15 days. Third group: was given standard forage and distilled water (as a drinking water) containing 40 mg lead/ L. daily for a period of 15 days. The fourth and fifth groups were treated with the same concentration of the second and third group separately daily for a period of 30 days. The results showed that treatment with lead caused a significant decrease in the concentration of each of total protein, albumin, globulin, glutathione GSH and the superoxide dismutase SOD activity in serum of treated rats compared with the control group. The reduction of the above mentioned parameters was progressive with the time of treatment. The result also showed that treatment with lead caused a significant increase in uric acid and malondialdhyde MDA in serum compared with control group. The results also showed that the decrease and increase were more prominent in rats treated with 40 mg lead/ L of drinking water. These results suggests that lead may induce oxidative stress in albino rats.
Keywords
Lead; Glutathione; Malondialdhyde; Uric acid; superoxide dismutase

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